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This study investigates the effects of Trametes versicolor (L.:Fr.) Pilat (TVP, also known as Yunzhi) on bone properties in diabetic rats. Forty-five 8-week-old male Wistar rats were fed either a chow diet (control, CON) or a high-fat diet throughout the study period of 28 days. Animals in the high-fat-diet group were injected nicotinamide and streptozotocin to induce diabetes mellitus (DM). The DM rats were divided into a group receiving distilled water (vehicle, VH) and another group receiving TVP at 0.1 g/kg-weight by gavage. Compared to the CON group, animals in the vehicle group demonstrated higher degree of hyperglucemia, smaller bone volume of tibia and femur, and lower femoral strength. Compared to the vehicle group, the TVP group demonstrated significantly lower postprandial blood sugar and femoral cortical porosity, increased bone volume of proximal tibia and femoral bone strength, and mitigated DM-induced deterioration of proximal tibial microarchitecture, as shown by reduced trabecular separation and larger trabecular number. The protective effect of TVP on bone properties was mediated through, in part, the improvement of hyperglycemic control in DM animals. Further study is needed to investigate whether TVP's osteoprotective effect is related to any mechanism that directly benefits the bone in rats with DM.
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